Welgan P, Meshkinpour H, Beeler M
Department of Medicine, University of California, Irvine.
Gastroenterology. 1988 May;94(5 Pt 1):1150-6. doi: 10.1016/0016-5085(88)90006-6.
The present investigation was designed to study the effect of anger on colon motor and myoelectric activity in irritable bowel syndrome. Patients with irritable bowel syndrome were compared with normal controls during resting and two anger stressors: criticism of performance on an intelligence test and during a delay of assistance for a diagnostic procedure. At rest patients with irritable bowel syndrome had higher motor and spike potential activity than normal subjects; however, the difference was only significant for spike activity. Anger significantly increased colon motor and spike potential activity in the groups compared with the resting state. Patients with irritable bowel syndrome produced significantly higher motor and spike potential activity when angered. They also reported themselves to be more hostile and appeared angrier than normal controls after the study. However, they did not report themselves to be more anxious or depressed, suggesting that the observed changes in colonic function of both groups were due to anger. Patients with irritable bowel syndrome scored significantly higher than controls on the Minnesota Multiphasic Personality Inventory scales of hypochondriasis, hysteria, and depression, but these personality factors did not significantly influence their anger level before the study. The results are discussed in terms of the role of learning in the colon and the abnormal reinforcement of bowel behavior in patients with irritable bowel syndrome.
本研究旨在探讨愤怒对肠易激综合征患者结肠运动和肌电活动的影响。在静息状态以及两种愤怒应激源（对智力测试表现的批评和诊断程序中援助延迟）期间，将肠易激综合征患者与正常对照进行比较。在静息状态下，肠易激综合征患者的运动和锋电位活动高于正常受试者；然而，差异仅在锋电位活动方面显著。与静息状态相比，愤怒显著增加了两组的结肠运动和锋电位活动。肠易激综合征患者在愤怒时产生的运动和锋电位活动显著更高。研究结束后，他们还报告自己比正常对照更具敌意且看起来更愤怒。然而，他们并未报告自己更焦虑或抑郁，这表明两组观察到的结肠功能变化是由愤怒引起的。在明尼苏达多相人格调查表的疑病症、癔症和抑郁量表上，肠易激综合征患者的得分显著高于对照组，但这些人格因素在研究前并未显著影响他们的愤怒水平。从学习在结肠中的作用以及肠易激综合征患者肠道行为的异常强化方面对结果进行了讨论。
