遗传性肥胖大鼠肝脏中的果糖-2,6-二磷酸
Fructose 2,6-bisphosphate in livers of genetically obese rats.
作者信息
Hue L, van de Werve G, Jeanrenaud B
出版信息
Biochem J. 1983 Sep 15;214(3):1019-22. doi: 10.1042/bj2141019.
Abstract
Livers of genetically obese (fa/fa) rats, starved for 24 h, contained more fructose 2,6-bisphosphate, glucose 6-phosphate, fructose 6-phosphate and glycogen, and more pyruvate kinase and phosphofructokinase 2 activities, than livers of control lean rats. These changes may be explained in terms of cyclic AMP concentration, which was decreased in livers of obese starved rats.
摘要
经过24小时饥饿的遗传性肥胖（fa/fa）大鼠的肝脏，与对照瘦鼠的肝脏相比，含有更多的果糖2,6-二磷酸、6-磷酸葡萄糖、6-磷酸果糖和糖原，以及更多的丙酮酸激酶和磷酸果糖激酶2活性。这些变化可以用环磷酸腺苷浓度来解释，在饥饿肥胖大鼠的肝脏中环磷酸腺苷浓度降低。
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