Claus T H, Nyfeler F, Muenkel H A, Burns M G, Pilkis S J
Biochem Biophys Res Commun. 1984 Jul 31;122(2):529-34. doi: 10.1016/s0006-291x(84)80065-0.
Fructose-2,6-bisphosphate levels in freeze-clamped livers of starved rats were 0.5 nmol/g liver. Oral administration of 1 g glucose per kg body weight to starved rats increased glycogen levels from 4 mg/g liver to 13.5 mg/g in 2 hr but did not significantly alter fructose-2,6-bisphosphate levels. The low level of this effector is consistent with an active gluconeogenic process and the results support the hypothesis that carbon atoms for glycogen synthesis can be derived from 3-carbon precursors via this pathway, even in the presence of glucose.
饥饿大鼠经冷冻钳夹处理的肝脏中果糖-2,6-二磷酸水平为0.5 nmol/g肝脏。给饥饿大鼠口服每千克体重1 g葡萄糖后，2小时内肝糖原水平从4 mg/g肝脏增加至13.5 mg/g，但果糖-2,6-二磷酸水平无显著变化。这种效应物的低水平与活跃的糖异生过程一致，结果支持了即使在有葡萄糖存在的情况下，糖原合成的碳原子也可通过该途径从三碳前体衍生而来的假说。
