Cheesman K L, Cheesman S D, Chatterton R T, Cohen M R
Fertil Steril. 1983 Nov;40(5):590-5.
The concentrations of pregnanediol-3-glucuronide (PGD) and pregnanolone (PN) were measured in daily morning urine specimens from 66 infertile women (40 with varying degrees of endometriosis and 26 control subjects) and correlated with daily changes in basal body temperature (BBT) and with midluteal levels of serum progesterone (P). PN and BBT rose at midcycle in women with endometriosis, as expected, indicating secretion of some P at that time. However, PGD, the major endpoint of P metabolism, was delayed in its excretion. Endometrial biopsies were similarly delayed (out of phase) in women with endometriosis, and a significantly higher incidence of follicular luteinization was seen. It appears that while P secretion begins at midcycle, the bulk of P secretion is delayed, perhaps because of the process of follicular luteinization, and that a shortened functional luteal phase thus exists in women with endometriosis.
在66名不孕女性（40名患有不同程度子宫内膜异位症，26名作为对照）每日晨尿样本中测量了孕二醇-3-葡萄糖醛酸苷（PGD）和孕烷醇酮（PN）的浓度，并将其与基础体温（BBT）的每日变化以及血清孕酮（P）的黄体中期水平进行关联。正如预期的那样，子宫内膜异位症女性的PN和BBT在月经周期中期升高，表明此时有一些P分泌。然而，P代谢的主要终产物PGD的排泄延迟。子宫内膜异位症女性的子宫内膜活检同样延迟（不同期），并且观察到卵泡黄素化的发生率显著更高。似乎虽然P分泌在月经周期中期开始，但大部分P分泌延迟，这可能是由于卵泡黄素化过程导致的，因此子宫内膜异位症女性存在功能黄体期缩短的情况。
