Cheesman K L, Chatterton R T, Cohen M R
Fertil Steril. 1982 Nov;38(5):542-8. doi: 10.1016/s0015-0282(16)46632-x.
The concentration of luteinizing hormone (LH), pregnanediol-3-glucuronide (PGD), and estriol-16-Glucuronide (E3G) were measured in daily morning urine specimens from 53 infertile women. In 26 of 29 women with various degrees of proven endometriosis, two distinct midcycle peaks of LH were found 2 or 3 days apart. Patients with LH peaks separated by 3 days had significantly more severe endometriosis than those with a single peak. Maximum concentrations of E3G were found to be delayed until after the first LH peak in these patients, and PGD concentrations did not rise until the time of the second LH peak, making actual luteal function of shorter duration than normal. From the data on LH, it appears that an inappropriate hormonal feedback mechanism is operative in endometriosis.
对53名不孕女性每日晨尿样本中的促黄体生成素（LH）、孕二醇 - 3 - 葡萄糖醛酸苷（PGD）和雌三醇 - 16 - 葡萄糖醛酸苷（E3G）浓度进行了测量。在29名患有不同程度确诊子宫内膜异位症的女性中，有26名女性在月经周期中期出现了两个不同的LH峰值，间隔2或3天。LH峰值间隔3天的患者比单峰患者的子宫内膜异位症明显更严重。在这些患者中，E3G的最大浓度延迟至第一个LH峰值之后才出现，而PGD浓度直到第二个LH峰值时才升高，使得实际黄体功能持续时间比正常情况短。从LH数据来看，似乎子宫内膜异位症存在不适当的激素反馈机制。
