Suzuki A, Kubota T, Oiyama H, Sono N, Nishi N
Nihon Naibunpi Gakkai Zasshi. 1983 Jul 20;59(7):1004-12. doi: 10.1507/endocrine1927.59.7_1004.
In order to investigate the relationship between the increment of plasma prolactin (PRL) levels and the change of plasma levels of PRL, DHEA-S, cortisol, aldosterone and 17 alpha OH delta 5-P were quantified by respective RIA in patients treated with TRH parenterally or with sulpiride orally. The results were as follows: During the infusion of TRH, plasma levels of PRL reached the maximal values within 30 min and then declined gradually in spite of continued TRH stimulation. Sulpiride given orally for 12 consecutive days in the luteal phase of the menstrual cycle caused a significant increase in the plasma PRL level. This increase was higher than that obtained in the experiment during the follicular phase. No significant change in the plasma level of 17 alpha OH delta 5-P was observed TRH sulpiride administration. In 3 out of 9 cases, plasma DHEA-S levels were elevated significantly on day 13 to 14 of the experimental course. These results indicate that the responsiveness of plasma levels of adrenal androgens to the raised plasma PRL level requires a certain period of time in the hyperprolactinemic state in the human female.
为了研究血浆催乳素（PRL）水平的升高与血浆PRL、硫酸脱氢表雄酮（DHEA-S）、皮质醇、醛固酮及17α-羟-△5-孕烯醇酮（17α OH delta 5-P）水平变化之间的关系，对接受TRH注射或口服舒必利治疗的患者，通过各自的放射免疫分析法（RIA）对上述指标进行了定量分析。结果如下：在注射TRH期间，血浆PRL水平在30分钟内达到最大值，之后尽管TRH持续刺激，仍逐渐下降。在月经周期的黄体期连续12天口服舒必利，可使血浆PRL水平显著升高。该升高幅度高于卵泡期实验中的升高幅度。给予TRH或舒必利后，未观察到血浆17α OH delta 5-P水平有显著变化。在9例患者中的3例，实验过程的第13至14天血浆DHEA-S水平显著升高。这些结果表明，在女性高催乳素血症状态下，肾上腺雄激素血浆水平对升高的血浆PRL水平的反应需要一定时间。
