Suzuki A, Sono N, Kido Y, Nishi N
Nihon Naibunpi Gakkai Zasshi. 1983 Dec 20;59(12):1905-11. doi: 10.1507/endocrine1927.59.12_1905.
Alterations of plasma TSH and PRL levels following various types of administration with TRH were studied in the luteal phase of women with normal menstrual cycles. The results were as follows: Plasma PRL response to a single i.v. injection of tRH with DHEA-S drop injection was not significantly different from that observed without it. The data suggest that DHEA-S does not affect the feedback mechanism in the short-term course of the experiment. Alterations in the plasma levels of PRL during intermittent as well as continuous infusion with TRH were quite different from those with TSH. Plasma TSH increased following the beginning of a continuous infusion with TRH and reached a peak at approximately 180 min, maintaining a plateau until the infusion was withheld. On the other hand, plasma PRL levels increased rapidly to reach peak levels in 30 min after the start of the infusion gradually following a decline in spite of continued TRH stimulation. Furthermore, a stepwise increase of TSH levels was observed following 4 intermittent injections of TRH; however, plasma PRL rapidly reached peak levels in 30 min following the 1st injection of TRH and a further 3 injections did not raise the levels of PRL. The results suggest that in humans, the synthesis and release of PRL occur independently in the pituitary.
在月经周期正常的女性黄体期，研究了不同方式给予促甲状腺激素释放激素（TRH）后血浆促甲状腺激素（TSH）和催乳素（PRL）水平的变化。结果如下：单次静脉注射TRH并滴注硫酸脱氢表雄酮（DHEA - S）时血浆PRL的反应与未滴注DHEA - S时观察到的反应无显著差异。数据表明，在实验的短期过程中，DHEA - S不影响反馈机制。TRH间歇输注和持续输注期间血浆PRL水平的变化与TSH的变化有很大不同。持续输注TRH开始后，血浆TSH升高，约180分钟时达到峰值，在停止输注前维持平台期。另一方面，尽管持续给予TRH刺激，但血浆PRL水平在输注开始后30分钟迅速升高至峰值水平，随后逐渐下降。此外，在4次间歇性注射TRH后观察到TSH水平呈逐步升高；然而，血浆PRL在首次注射TRH后30分钟迅速达到峰值水平，随后的3次注射并未使PRL水平升高。结果表明，在人类中，PRL的合成和释放是在垂体中独立发生的。
