Mueller C B, Ames F, Anderson G D
Surgery. 1978 Feb;83(2):123-32.
The forces of mortality created by cancer of the breast have been examined utilizing data collected during the past 19 years by the Syracuse, N. Y., Upstate Medical Center Cancer Registry on 3,558 women. Except for 15 lost to follow-up, all have been contacted annually through 1974 or until death. Time and cause were recorded for all deaths. In April, 1975, 1,883 remain alive and in the registry and 1,660 women have died. Using life-table analyses and considering deaths due only to breast cancer, mortality rates were calculated for three age groups--21 to 50 years, 51 to 70 years, and 71 to 100 years. Breast cancer expresses its lethality most vigorously in the oldest group. The half-death time (50% mortality rate) for the youngest group was 13 years, for the middle group 8 years, and for the oldest group 5 years. The rate of dying was a function of both age and stage at diagnosis. At 16 to 18 years after diagnosis, deaths due to breast cancer begin to disappear. Eighty-eight percent of the women who died following a diagnosis of cancer of the breast have died of their breast cancer. Age as well as stage at diagnosis are significant determinants on the length of survival and cause of death.
利用纽约州锡拉丘兹市北部医疗中心癌症登记处在过去19年里收集的3558名女性的数据，对乳腺癌造成的死亡率进行了研究。除15人失访外，截至1974年每年都对所有人进行了随访，直至死亡。记录了所有死亡的时间和原因。1975年4月，仍有1883人存活并在登记册中，1660名女性已经死亡。采用寿命表分析并仅考虑因乳腺癌导致的死亡，计算了三个年龄组（21至50岁、51至70岁和71至100岁）的死亡率。乳腺癌在年龄最大的组中致死性最强。最年轻组的半数死亡时间（死亡率50%）为13年，中间组为8年，最年长组为5年。死亡发生率是诊断时年龄和分期的函数。诊断后16至18年，因乳腺癌导致的死亡开始减少。在被诊断患有乳腺癌后死亡的女性中，88%死于乳腺癌。诊断时的年龄以及分期是生存时间长度和死亡原因的重要决定因素。
