C3b和C3bi的受体促进吞噬作用，但不会促使人类吞噬细胞释放毒性氧。
Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.
作者信息
Wright S D, Silverstein S C
出版信息
J Exp Med. 1983 Dec 1;158(6):2016-23. doi: 10.1084/jem.158.6.2016.
Abstract
We have measured the release of H2O2 from granulocytes, monocytes, and macrophages during spreading on ligand-coated culture surfaces. While IgG-coated surfaces stimulate vigorous release of H2O2, neither C3b- nor C3bi-coated surfaces promoted appreciable release of H2O2 despite full ligation of C3b and C3bi receptors. We also measured release of H2O2 from cultured monocytes spreading on surfaces coated with both fibronectin and C3. Under such circumstances, the C3 receptors elicit a strong phagocytic response, but no H2O2 release was recorded. We conclude that the C3b and C3bi receptors of monocytes and granulocytes do not signal the generation of toxic oxygen intermediates from these cells.
摘要
我们已经测量了粒细胞、单核细胞和巨噬细胞在铺展于配体包被的培养表面时过氧化氢（H₂O₂）的释放情况。虽然IgG包被的表面会刺激H₂O₂的大量释放，但C3b包被的表面和C3bi包被的表面均未促进H₂O₂的明显释放，尽管C3b和C3bi受体已完全结合。我们还测量了培养的单核细胞在同时包被纤连蛋白和C3的表面上铺展时H₂O₂的释放情况。在这种情况下，C3受体引发强烈的吞噬反应，但未记录到H₂O₂的释放。我们得出结论，单核细胞和粒细胞的C3b和C3bi受体不会引发这些细胞产生毒性氧中间体的信号。
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