免疫颠覆活动及其在牙周生态失调中的作用。
: Immune subversion activities and role in periodontal dysbiosis.
作者信息
Hajishengallis George, Diaz Patricia I
机构信息
Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, 240 S. 40 Street, Philadelphia, PA 19104, USA.
Division of Periodontology, Department of Oral Health and Diagnostic Sciences, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA.
出版信息
Curr Oral Health Rep. 2020 Mar;7(1):12-21. doi: 10.1007/s40496-020-00249-3. Epub 2020 Jan 10.
PURPOSE OF REVIEW
This review summarizes mechanisms by which interacts with community members and the host so that it can persist in the periodontium under inflammatory conditions that drive periodontal disease.
RECENT FINDINGS
Recent advances indicate that, in great part, the pathogenicity of is dependent upon its ability to establish residence in the subgingival environment and to subvert innate immunity in a manner that uncouples the nutritionally favorable (for the bacteria) inflammatory response from antimicrobial pathways. While the initial establishment of is dependent upon interactions with early colonizing bacteria, the immune subversion strategies of in turn benefit co-habiting species.
SUMMARY
Specific interspecies interactions and subversion of the host response contribute to the emergence and persistence of dysbiotic communities and are thus targets of therapeutic approaches for the treatment of periodontitis.
综述目的
本综述总结了[具体细菌名称未给出]与社区成员和宿主相互作用的机制，以便它能够在驱动牙周疾病的炎症条件下在牙周组织中持续存在。
最新发现
最近的进展表明，在很大程度上，[具体细菌名称未给出]的致病性取决于其在龈下环境中定植的能力，以及以一种将（对细菌有利的）营养性炎症反应与抗菌途径解耦联的方式颠覆固有免疫的能力。虽然[具体细菌名称未给出]的初始定植依赖于与早期定植细菌的相互作用，但其免疫颠覆策略反过来又有利于共生物种。
总结
特定的种间相互作用和宿主反应的颠覆促成了生态失调群落的出现和持续存在，因此是治疗牙周炎的治疗方法的靶点。
Zotero 插件