Hasstedt S J, Wilson D E, Edwards C Q, Cannon W N, Carmelli D, Williams R R
Am J Med Genet. 1983 Oct;16(2):179-88. doi: 10.1002/ajmg.1320160208.
Likelihood analysis using the mixed model of quantitative plasma Lp(a) measurements on members of a large pedigree provided evidence that high levels of Lp(a) are inherited as a dominant major gene with polygenic background. The dominant allele frequency was estimated as 0.10. The major gene and polygenic components together accounted for 95% of the variation seen in the measurements. The major gene index and OBP plots, methods that do not allow for the presence of both components, favored the polygenic model over the major gene model as the mode of inheritance. No association was found with any of the lipids, lipoproteins or apolipoproteins considered.
利用大型家系成员血浆Lp(a)定量测量的混合模型进行似然性分析，结果表明，高水平的Lp(a)作为一种具有多基因背景的显性主基因遗传。显性等位基因频率估计为0.10。主基因和多基因成分共同占测量中观察到变异的95%。主基因指数和OBP图这两种不考虑两种成分同时存在的方法，更倾向于多基因模型而非主基因模型作为遗传模式。在所考虑的任何脂质、脂蛋白或载脂蛋白中均未发现关联。
