Livingston C D, Levine B A, Sirinek K R
Am J Surg. 1983 Dec;146(6):734-7. doi: 10.1016/0002-9610(83)90329-x.
Using an animal model with bacteria delivered through the respiratory tract, the relative protective effects of subcutaneous and intraperitoneal splenic autotransplants were compared. Animals with intraperitoneal implants demonstrated a mortality not different from that in control animals and an early mortality significantly lower than found in splenectomized animals. Subcutaneous splenic autotransplantation provided no protective effect. The inability of extraperitoneal subcutaneous implants to protect against postsplenectomy pulmonary sepsis in our model suggests that subcutaneous splenic autotransplantation is an inappropriate alternative to intraperitoneal splenic autotransplantation in the clinical setting.
利用通过呼吸道接种细菌的动物模型，比较了皮下和腹腔内脾自体移植的相对保护作用。接受腹腔内植入的动物死亡率与对照动物无异，且早期死亡率显著低于脾切除动物。皮下脾自体移植未提供保护作用。在我们的模型中，腹膜外皮下植入物无法预防脾切除术后肺部感染，这表明在临床环境中，皮下脾自体移植并非腹腔内脾自体移植的合适替代方法。
