Livingston C D, Levine B A, Sirinek K R
Surg Gynecol Obstet. 1983 Jun;156(6):761-6.
One hundred and ten Sprague-Dawley rats were randomly assigned to one of four treatment groups: 1, sham control; 2, splenectomy; 3, splenectomy and implantation of diced splenic tissue among the leaves of the small intestinal mesentery, and 4, splenectomy and intraportal injection of emulsified splenic tissue. Twelve weeks postoperatively, all of the rats were challenged with Type III Streptococcus pneumoniae by transtracheal injection. Rats with intraportal splenic autotransplants had an early mortality significantly higher than that of asplenic rats. Rats with small intestinal mesentery implants had a mortality not significantly different from that of sham control rats but significantly lower than that of rats that underwent splenectomy. Thus, intraperitoneal splenic autotransplantation provides a protective effect against postsplenectomy pulmonary sepsis and serves as a method for preservation of splenic function.
110只Sprague-Dawley大鼠被随机分为四个治疗组之一：1. 假手术对照组；2. 脾切除术组；3. 脾切除术并将切碎的脾组织植入小肠系膜叶间组；4. 脾切除术并经门静脉注射乳化脾组织组。术后12周，所有大鼠经气管注射III型肺炎链球菌进行攻击。经门静脉自体脾移植的大鼠早期死亡率显著高于无脾大鼠。小肠系膜植入物的大鼠死亡率与假手术对照组大鼠无显著差异，但显著低于接受脾切除术的大鼠。因此，腹腔内自体脾移植对脾切除术后肺部败血症具有保护作用，并可作为一种保留脾功能的方法。
