Birgegård G, Högman C, Killander A, Wide L
Vox Sang. 1978;34(2):65-70. doi: 10.1111/j.1423-0410.1978.tb03724.x.
Serum ferritin estimation has been shown to be a reliable test to reveal iron deficiency. Such estimations have been made in groups of male blood donors with a varying number of previous phlebotomies and a mean interval between donations of 9.9 +/- 1.7 SD weeks. It was found that the mean ferritin level was significantly (p less than 0.001) lower in the blood donors than in nondonors. After 6-8 phlebotomies it was about 40% lower. Subnormal ferritin values were found in 10% of the donors, almost exclusively among those who had taken less than 1,000 mg of iron supplementation since the last donation. It is concluded that with a donation interval of about 10 weeks, there is a considerable risk for iron deficiency after about 6 donations. This risk is far less if more than 1,000 mg of iron supplementation is taken between phlebotomies. A role for serum ferritin estimation in monitoring donation intervals and/or iron therapy is suggested.
血清铁蛋白测定已被证明是一项揭示缺铁情况的可靠检测方法。在不同既往采血次数且两次献血平均间隔为9.9±1.7标准差周的男性献血者群体中进行了此类测定。结果发现，献血者的平均铁蛋白水平显著低于非献血者（p＜0.001）。经过6 - 8次采血后，平均铁蛋白水平约低40%。10%的献血者铁蛋白值低于正常范围，几乎都在自上次献血以来铁补充量少于1000毫克的人群中。得出的结论是，若献血间隔约为10周，大约6次献血后缺铁风险相当大。若在两次采血之间补充超过1000毫克的铁，这种风险则会小得多。建议血清铁蛋白测定在监测献血间隔和/或铁治疗方面发挥作用。
