Nyce J W, Magee P N, Hard G C, Schwartz A G
Carcinogenesis. 1984 Jan;5(1):57-62. doi: 10.1093/carcin/5.1.57.
Long-term administration of dehydroepiandrosterone (DHEA) to Balb/c mice significantly inhibits the rate of appearance of 1,2-dimethylhydrazine (DMH)-induced macroscopic colon and anal tumors and microscopic precursor and malignant lesions. The steroid, which has previously been shown to inhibit spontaneous breast cancer and chemically induced lung tumors in mice, may find application as a chemopreventive in individuals at high risk for developing colon cancer.
对Balb/c小鼠长期给予脱氢表雄酮（DHEA）可显著抑制1,2-二甲基肼（DMH）诱导的肉眼可见的结肠和肛门肿瘤以及显微镜下的癌前病变和恶性病变的出现率。这种类固醇此前已被证明可抑制小鼠的自发性乳腺癌和化学诱导的肺癌，它可能会作为一种化学预防剂应用于患结肠癌风险较高的个体。
