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丁基羟基甲苯对二甲基肼诱导的大鼠结肠癌发生无影响。

Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats.

作者信息

Barbolt T A, Abraham R

出版信息

Experientia. 1979 Feb 15;35(2):257-8. doi: 10.1007/BF01920650.

DOI:10.1007/BF01920650
PMID:421853
Abstract

Rats were given 6600 ppm of butylated hydroxytoluene (BHT) in the diet along with 10 weekly oral doses of dimethylhydrazine (DMH, 30 MG/KG). The incidence and mean number of colonic tumors produced were similar to that of rats given DMH alone. Thus, BHT did not provide any protective effect against colon carcinogenesis.

摘要

给大鼠喂食含6600 ppm丁基羟基甲苯（BHT）的饲料，并每周口服10次二甲基肼（DMH，30毫克/千克）。所产生的结肠肿瘤的发生率和平均数量与仅给予DMH的大鼠相似。因此，BHT对结肠癌发生没有提供任何保护作用。

相似文献

1
Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats.丁基羟基甲苯对二甲基肼诱导的大鼠结肠癌发生无影响。
Experientia. 1979 Feb 15;35(2):257-8. doi: 10.1007/BF01920650.
2
Effect of dietary sodium ascorbate on 1,2-dimethylhydrazine- or methylnitrosourea-induced colon carcinogenesis in rats.膳食抗坏血酸钠对1,2 - 二甲基肼或甲基亚硝基脲诱导的大鼠结肠癌发生的影响。
Carcinogenesis. 1982;3(9):1097-9. doi: 10.1093/carcin/3.9.1097.
3
Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine.在给予二甲基肼的大鼠中，麸皮对胆盐结肠促癌作用的抑制。
Exp Mol Pathol. 1980 Oct;33(2):133-43. doi: 10.1016/0014-4800(80)90014-3.
4
Selective protective effect of butylated hydroxytoluene against 1,2-dimethylhydrazine carcinogenesis in BALB/c mice.
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Cancer Lett. 1983 May;19(1):1-6. doi: 10.1016/0304-3835(83)90127-1.
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Potentiation of dimethylhydrazine bowel carcinogenesis in rats.大鼠中二甲肼肠道致癌作用的增强
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Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.在大鼠多器官致癌模型中，α-生育酚、叔丁基对苯二酚、没食子酸丙酯和丁基羟基甲苯对致癌作用的影响
Carcinogenesis. 1993 Nov;14(11):2359-64. doi: 10.1093/carcin/14.11.2359.

本文引用的文献

1
Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin.酚类抗氧化剂和乙氧喹对多环烃致癌和毒性作用的抑制
J Natl Cancer Inst. 1972 May;48(5):1425-30.
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Effect of the antioxidant butylated hydroxytoluene (BHT) on the metabolism of the carcinogens N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide.抗氧化剂丁基羟基甲苯（BHT）对致癌物N-2-芴基乙酰胺和N-羟基-N-2-芴基乙酰胺代谢的影响。
Food Cosmet Toxicol. 1973 Apr;11(2):209-17. doi: 10.1016/s0015-6264(73)80487-0.
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Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats.
大鼠结肠和小肠化学诱导肿瘤的形态发生
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4
Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats.抗氧化剂与致癌作用：丁基羟基甲苯可抑制大鼠体内由N-2-芴基乙酰胺和N-羟基-N-2-芴基乙酰胺诱导的癌症发生，而二苯胺对苯二胺则无此作用。
Food Cosmet Toxicol. 1973 Apr;11(2):199-207. doi: 10.1016/s0015-6264(73)80486-9.
5
The effect of substituted phenols on liver weights and liver enzymes in the rat: structure-activity relationships.取代酚类对大鼠肝脏重量和肝酶的影响：构效关系
Food Cosmet Toxicol. 1969 Nov;7(6):603-19. doi: 10.1016/s0015-6264(69)80463-3.
6
Investigations into the metabolism and mode of action of the colon carcinogen 1, 2-dimethylhydrazine.对结肠致癌物1,2 - 二甲基肼的代谢及作用方式的研究。
Cancer. 1975 Dec;36(6 Suppl):2407-12. doi: 10.1002/1097-0142(197512)36:6<2407::aid-cncr2820360620>3.0.co;2-w.
7
Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram.双硫仑对二甲基肼诱导的大肠肿瘤形成的抑制作用。
J Natl Cancer Inst. 1975 Apr;54(4):1005-6. doi: 10.1093/jnci/54.4.1005.
8
Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane.
Food Cosmet Toxicol. 1977 Apr;15(2):139-41. doi: 10.1016/s0015-6264(77)80320-9.
9
The effect of bran on dimethylhydrazine-induced colon carcinogenesis in the rat.麸皮对二甲基肼诱导的大鼠结肠癌发生的影响。
Proc Soc Exp Biol Med. 1978 Apr;157(4):656-9. doi: 10.3181/00379727-157-40115.
10
Effects of administration to mice of butylated hydroxyanisole by oral intubation on benzo[a]pyrene-induced pulmonary adenoma formation and metabolism of benzo[a]pyrene.经口插管给小鼠施用丁基羟基茴香醚对苯并[a]芘诱导的肺腺瘤形成及苯并[a]芘代谢的影响。
J Natl Cancer Inst. 1978 Mar;60(3):605-9. doi: 10.1093/jnci/60.3.605.