丁基羟基甲苯对二甲基肼诱导的大鼠结肠癌发生无影响。
Lack of effect of butylated hydroxytoluene on dimethylhydrazine-induced colon carcinogenesis in rats.
作者信息
Barbolt T A, Abraham R
出版信息
Experientia. 1979 Feb 15;35(2):257-8. doi: 10.1007/BF01920650.
PMID:421853
Abstract
Rats were given 6600 ppm of butylated hydroxytoluene (BHT) in the diet along with 10 weekly oral doses of dimethylhydrazine (DMH, 30 MG/KG). The incidence and mean number of colonic tumors produced were similar to that of rats given DMH alone. Thus, BHT did not provide any protective effect against colon carcinogenesis.
摘要
给大鼠喂食含6600 ppm丁基羟基甲苯（BHT）的饲料，并每周口服10次二甲基肼（DMH，30毫克/千克）。所产生的结肠肿瘤的发生率和平均数量与仅给予DMH的大鼠相似。因此，BHT对结肠癌发生没有提供任何保护作用。
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