Vasil'eva S V, Tonkal' T E
Genetika. 1983 Nov;19(11):1778-85.
In experiments with chemical mutagens (alkylating agents MNU, ENU, MMS and EMS), para-aminobenzoic acid (PABA) sharply inhibited the inducible processes in Escherichia coli, namely, mutagenesis, induction of lambda prophage and W-reactivation of UV-irradiated phage lambda. Based on experimental studies of E. coli strains deficient in different steps of DNA repair, the conclusion was made that PABA participates in regulation of the branch of DNA repair that is controlled by recA+ recF+ alleles.
在使用化学诱变剂(烷基化剂MNU、ENU、MMS和EMS)进行的实验中,对氨基苯甲酸(PABA)显著抑制了大肠杆菌中的诱导过程,即诱变、λ原噬菌体的诱导以及紫外线照射的λ噬菌体的W复活。基于对DNA修复不同步骤缺陷的大肠杆菌菌株的实验研究,得出结论:PABA参与由recA+recF+等位基因控制的DNA修复分支的调控。