Fahey J L, Prince H, Weaver M, Groopman J, Visscher B, Schwartz K, Detels R
Am J Med. 1984 Jan;76(1):95-100. doi: 10.1016/0002-9343(84)90756-3.
Quantitative measurements of the immune cell subgroups, T helper (Leu 3+/OKT4+) cells and T suppressor/cytotoxic (Leu 2+/OKT8+) cells, were made in patients having acquired immune deficiency syndrome (AIDS) with Kaposi's sarcoma and in patients with AIDS and opportunistic infection, as well as in three other relevant populations. These included patients with lymphadenopathy syndrome, e.g., homosexually active males with lymphadenopathy who sought medical care for additional symptoms, and healthy male homosexuals, as well as a control population. Decrease in the number of T helper cells is characteristic of AIDS with Kaposi's sarcoma or opportunistic infection. Augmentation of the T suppressor/cytotoxic cell population is rare in AIDS with Kaposi's sarcoma but is more frequent in AIDS with opportunistic infection. Augmentation of the T suppressor/cytotoxic cell population, however, may occur in a variety of circumstances, including cytomegalovirus and other viral infections, in healthy, homosexually active males, and in otherwise healthy hemophiliac subjects receiving factor VIII treatment. Reduced T helper:T suppressor/cytotoxic cell ratio can be caused by either decrease in the number of T helper cells or augmentation of the T suppressor/cytotoxic cell population. Lowered T helper:T suppressor/cytotoxic cell ratio does not, by itself, help to distinguish between AIDS and other causes of reduced ratios. Quantitative measurements are needed to define the T subset changes. AIDS is characterized by decrease in the number of T helper cells and reduced T helper:T suppressor/cytotoxic cell ratio. The T helper (Leu 3+) and T suppressor/cytotoxic (Leu 2+) cell subpopulations can change independently. Identification of decrease in the number of T helper cells as an alteration that occurs independently of numerical change in other lymphoid subpopulations, such as T suppressor/cytotoxic cells and B cells, and the close association of the decrease in the number of T helper cells with AIDS are consistent with a distinct pathogenesis (and cause) for AIDS.
对患有卡波西肉瘤的获得性免疫缺陷综合征（AIDS）患者、患有AIDS和机会性感染的患者以及其他三个相关人群的免疫细胞亚群，即辅助性T细胞（Leu 3+/OKT4+）和抑制/细胞毒性T细胞（Leu 2+/OKT8+）进行了定量测量。这些人群包括淋巴结病综合征患者，例如因出现其他症状而寻求医疗护理的有淋巴结病的性活跃同性恋男性、健康的男性同性恋者以及一个对照人群。辅助性T细胞数量减少是患有卡波西肉瘤或机会性感染的AIDS的特征。抑制/细胞毒性T细胞群体增加在患有卡波西肉瘤的AIDS中很少见，但在患有机会性感染的AIDS中更常见。然而，抑制/细胞毒性T细胞群体增加可能发生在多种情况下，包括巨细胞病毒和其他病毒感染、健康的性活跃同性恋男性以及接受因子VIII治疗的其他健康血友病患者。辅助性T细胞与抑制/细胞毒性T细胞的比例降低可能是由于辅助性T细胞数量减少或抑制/细胞毒性T细胞群体增加所致。辅助性T细胞与抑制/细胞毒性T细胞比例降低本身并不能帮助区分AIDS与其他导致比例降低的原因。需要进行定量测量来确定T细胞亚群的变化。AIDS的特征是辅助性T细胞数量减少以及辅助性T细胞与抑制/细胞毒性T细胞的比例降低。辅助性T细胞（Leu 3+）和抑制/细胞毒性T细胞（Leu 2+）亚群可以独立变化。将辅助性T细胞数量减少确定为一种独立于其他淋巴细胞亚群（如抑制/细胞毒性T细胞和B细胞）数量变化而发生的改变，以及辅助性T细胞数量减少与AIDS的密切关联，与AIDS独特的发病机制（和病因）相一致。
