Katner H P, deShazo R D, Pankey G A, Andes W A, Daul C B, Cortez L, Dalovisio J, Bozelka B
J Allergy Clin Immunol. 1987 Feb;79(2):364-70. doi: 10.1016/0091-6749(87)90157-6.
Patients with the acquired immune deficiency syndrome (AIDS) have depressed cell-mediated immunity partially explained by a depletion of helper-inducer T-lymphocytes. We questioned if the remaining elements of the mononuclear cell (MNC) population also played a part in the immunologic abnormalities noted. We therefore evaluated the ability of MNC populations from homosexuals with AIDS and AIDS-associated conditions to suppress the mitogenic responses of control MNCs in an assay of "spontaneous suppressor" cell activity (SSCA). Asymptomatic homosexuals and homosexuals with chronic lymphadenopathy, Kaposi's sarcoma, or opportunistic infections (OIs) had levels of SSCA equal to or greater than that of control subjects. Levels were significantly higher in patients with lymphadenopathy (p less than or equal to 0.1) and in patients with OI (p less than or equal to 0.05). Although percentages of Ia+ cells were increased in all homosexual groups and highest in patients with OIs (p less than or equal to 0.05), percentages of either monocytes or suppressor/cytotoxic T-lymphocytes, potential mediators of SSCA function, did not correlate with levels of SSCA observed. Therefore, patients with AIDS and AIDS-associated conditions have MNC populations that appear to interact in producing normal or augmented down regulation of residual T-lymphocyte function, even in the face of helper/inducer T-lymphocyte depletion.
获得性免疫缺陷综合征（AIDS）患者的细胞介导免疫功能低下，部分原因是辅助诱导性T淋巴细胞耗竭。我们质疑单核细胞（MNC）群体的其余成分是否也在所述免疫异常中起作用。因此，我们在一项“自发抑制细胞”活性（SSCA）检测中，评估了患有AIDS和AIDS相关疾病的同性恋者的MNC群体抑制对照MNC有丝分裂反应的能力。无症状同性恋者以及患有慢性淋巴结病、卡波西肉瘤或机会性感染（OI）的同性恋者的SSCA水平等于或高于对照受试者。淋巴结病患者（p≤0.1）和OI患者（p≤0.05）的水平显著更高。尽管所有同性恋群体中Ia +细胞的百分比均增加，且在OI患者中最高（p≤0.05），但作为SSCA功能潜在介质的单核细胞或抑制/细胞毒性T淋巴细胞的百分比与观察到的SSCA水平均无相关性。因此，患有AIDS和AIDS相关疾病的患者的MNC群体似乎在对残余T淋巴细胞功能产生正常或增强的下调中相互作用，即使存在辅助/诱导性T淋巴细胞耗竭的情况。
