Wolff M, Regnier B, Daldoss C, Nkam M, Vachon F
Antimicrob Agents Chemother. 1984 Sep;26(3):289-91. doi: 10.1128/AAC.26.3.289.
We evaluated the diffusion of pefloxacin into the cerebrospinal fluid (CSF) in 15 patients with bacterial meningitis or ventriculitis, 14 of whom were treated with other antibiotics. Three doses of pefloxacin were administered at 12-h intervals to 11 patients intravenously and to 4 patients orally. Individual doses were 7.5 mg/kg in seven patients and 15 mg/kg in eight patients. Plasma and CSF levels were determined by a high-performance liquid chromatographic assay. The concentrations of pefloxacin in CSF were measured 2 h after the third intravenous dose and 4 h after the third oral dose. In patients receiving 7.5 mg/kg, peak levels in plasma ranged from 6.8 to 16 micrograms/ml, and trough levels were from 2 to 7.5 micrograms/ml. Concentrations in CSF ranged from 2.4 to 9 micrograms/ml. In patients receiving 15 mg/kg, peak levels in plasma ranged from 14 to 18.6 micrograms/ml, and trough levels were from 4 to 13.2 micrograms/ml. Concentrations in CSF ranged from 6.5 to 13 micrograms/ml. These preliminary data indicate that pefloxacin diffuses well into the CSF of patients with inflamed meninges.
我们评估了培氟沙星在15例细菌性脑膜炎或脑室炎患者脑脊液（CSF）中的扩散情况，其中14例患者正在接受其他抗生素治疗。11例患者静脉注射、4例患者口服培氟沙星，每12小时给药3次。7例患者的单次剂量为7.5mg/kg，8例患者为15mg/kg。采用高效液相色谱法测定血浆和脑脊液水平。在第三次静脉给药后2小时和第三次口服给药后4小时测量脑脊液中培氟沙星的浓度。接受7.5mg/kg剂量的患者，血浆峰值水平为6.8至16μg/ml，谷值水平为2至7.5μg/ml。脑脊液浓度为2.4至9μg/ml。接受15mg/kg剂量的患者，血浆峰值水平为14至18.6μg/ml，谷值水平为4至13.2μg/ml。脑脊液浓度为6.5至13μg/ml。这些初步数据表明，培氟沙星能很好地扩散到脑膜发炎患者的脑脊液中。
