Abou-Saleh M T, Coppen A
Br J Psychiatry. 1983 Dec;143:601-3. doi: 10.1192/bjp.143.6.601.
Two hundred inpatients suffering from primary depressive illness were studied. Seventy eight of the patients were treated by electroconvulsive therapy (ECT) and 122 patients received antidepressant medication. Response to ECT and antidepressant medication at 4 weeks showed a curvilinear relationship to Newcastle scores. Patients with Newcastle scores in the middle range (4-8) showed significantly higher percentage improvement than those with low (0-3) and high (9-12) scores. Ninety five patients with unipolar depression who received lithium therapy for one year were also studied. Response to lithium showed a linear relationship to Newcastle scores in these patients. It is suggested that these differences in response to antidepressant therapies reflect the heterogeneity of depressive illness.
对200名原发性抑郁症住院患者进行了研究。其中78名患者接受了电休克治疗（ECT），122名患者接受了抗抑郁药物治疗。4周时对ECT和抗抑郁药物的反应与纽卡斯尔评分呈曲线关系。纽卡斯尔评分处于中等范围（4 - 8）的患者改善百分比显著高于评分低（0 - 3）和高（9 - 12）的患者。还对95名单相抑郁症患者进行了研究，这些患者接受了一年的锂盐治疗。在这些患者中，对锂盐的反应与纽卡斯尔评分呈线性关系。提示抗抑郁治疗反应的这些差异反映了抑郁症的异质性。
