Dhodapkar B S, Vegad J L, Kolte G N, Dhawedkar R G
Res Vet Sci. 1983 Nov;35(3):259-72.
It was possible to produce an active Arthus reaction in chicken skin which resulted in gross and microscopic lesions. Histologically, the reaction was predominantly thrombotic in nature and restricted to the upper dermis. The thrombi appeared to develop as a consequence of immune complex deposition with adherence and aggregation of thrombocytes at the vascular endothelium. Thrombosis induced widespread necrosis and haemorrhage and vasculitis occurred in the lower dermis. Up to four hours after inoculation, the cell population comprised an infiltration of heterophils, monocytes and basophils, suggesting an immediate hypersensitivity reaction. This was followed by an Arthus type reaction for four to 12 hours involving both heterophils and monocytes. A characteristic feature was the development of early perivascular lymphoid foci. After 12 hours the reaction resembled a delayed hypersensitivity. The use of colloidal carbon suggested that whereas phagocytic activity of the heterophils and basophils appeared sensitisation dependent, that of thrombocytes and monocytes was independent of it. The findings indicate that in the Arthus reaction in the chicken the thrombocyte appears to be the principal cell producing tissue damage by thrombosis. A comparison was made with the active Arthus reaction in the rabbit.
在鸡皮中能够产生一种活跃的阿瑟斯反应，该反应会导致肉眼可见和微观的病变。从组织学上看，该反应本质上主要是血栓形成，且局限于真皮上层。血栓似乎是免疫复合物沉积以及血小板在血管内皮细胞处黏附和聚集的结果。血栓形成引发广泛的坏死和出血，并且真皮下层发生血管炎。接种后长达4小时，细胞群体包括嗜异性粒细胞、单核细胞和嗜碱性粒细胞浸润，提示速发型超敏反应。随后在4至12小时出现阿瑟斯型反应，涉及嗜异性粒细胞和单核细胞。一个特征性表现是早期血管周围淋巴集结的形成。12小时后，该反应类似于迟发型超敏反应。使用胶体碳表明，嗜异性粒细胞和嗜碱性粒细胞的吞噬活性似乎依赖于致敏作用，而血小板和单核细胞的吞噬活性则与之无关。这些发现表明，在鸡的阿瑟斯反应中，血小板似乎是通过血栓形成导致组织损伤的主要细胞。并与兔的活跃阿瑟斯反应进行了比较。
