后续剂量的氯化甲基汞或氯化汞之间的相互作用对每次单独剂量汞的胆汁排泄的影响。

The effect of interaction between subsequent doses of MeHgCl or HgCl2 on the biliary excretion of mercury from each individual dose.

作者信息

Cikrt M, Magos L, Snowden R T

出版信息

Toxicol Lett. 1984 Feb;20(2):189-94. doi: 10.1016/0378-4274(84)90146-2.

Abstract

The biliary excretion and organ distribution of mercury was investigated in male rats which received mercuric chloride (HgCl2) (0.65 mg/kg Hg2+) or methylmercury chloride (MeHgCl) (2 mg/kg Hg) i.p. and 48 h later the same compound i.v. Mercury was labelled with 203Hg either in the first or second injection. In controls saline was substituted for unlabelled mercury. In one experiment rats pretreated with HgCl2 were given Me203HgCl 48 h later. The biliary excretion and organ distribution of 203Hg were not influenced by the injection of cold MeHgCl given before or after Me203HgCl or by HgCl2 given 48 h after 203HgCl2. HgCl2 given 48 h before the injection of 203HgCl2 or Me203HgCl significantly decreased biliary excretion of 203Hg despite increased 203Hg levels in blood and liver.

摘要

在雄性大鼠中研究了汞的胆汁排泄和器官分布，这些大鼠腹腔注射氯化汞（HgCl₂）（0.65 mg/kg Hg²⁺）或甲基氯化汞（MeHgCl）（2 mg/kg Hg），48小时后静脉注射相同化合物。汞在第一次或第二次注射时用²⁰³Hg标记。对照组用生理盐水替代未标记的汞。在一项实验中，用HgCl₂预处理的大鼠在48小时后给予Me²⁰³HgCl。²⁰³Hg的胆汁排泄和器官分布不受在Me²⁰³HgCl之前或之后注射冷MeHgCl或在²⁰³HgCl₂后48小时给予HgCl₂的影响。在注射²⁰³HgCl₂或Me²⁰³HgCl前48小时给予HgCl₂，尽管血液和肝脏中²⁰³Hg水平升高，但显著降低了²⁰³Hg的胆汁排泄。