Sontheimer R D, Bergstresser P R, Gailiunas P, Helderman J H, Gilliam J N
Transplantation. 1984 Feb;37(2):168-74. doi: 10.1097/00007890-198402000-00011.
As an initial attempt to gain a better understanding of the basis for the increased incidence of ultraviolet-light-related skin cancer in chronically immunosuppressed human renal allograft recipients, we have compared both morphological and functional characteristics of epidermal Langerhans cell (LC) populations present in the forearm skin of nine such patients with those of age, sex, and race-matched controls. The LC surface densities in vacuum-induced blister-derived epidermal sheets taken simultaneously from extensor and flexor forearm skin of the patients were significantly lower than those observed in the controls. The most abnormal LC densities seen were in the patients' extensor forearm skin. Likewise there were disturbances in LC distribution and morphology that were most marked in the extensor forearm skin of patients. Differences in the alloantigen-presenting capacity of LCs present in epidermal cell suspensions prepared from patient and control forearm skin were also noted--however, these differences were not as great as were the LC density differences. The alloantigen-presenting capacity of patients' LCs was depressed proportionately more than was the alloantigen presenting capacity of their peripheral blood mononuclear cells. These results demonstrate that the LC population is clearly perturbed in human renal allograft recipients and that this perturbation is greatest in a sun-exposed region of skin.
作为初步尝试，为了更好地理解长期免疫抑制的人类肾移植受者中与紫外线相关的皮肤癌发病率增加的基础，我们比较了9例此类患者前臂皮肤中表皮朗格汉斯细胞（LC）群体的形态学和功能特征，以及年龄、性别和种族匹配的对照组的相应特征。从患者伸肌和屈肌前臂皮肤同时获取的真空诱导水疱来源的表皮片中，LC表面密度显著低于对照组。所见最异常的LC密度出现在患者的伸肌前臂皮肤中。同样，LC分布和形态也存在紊乱，在患者的伸肌前臂皮肤中最为明显。还注意到从患者和对照前臂皮肤制备的表皮细胞悬液中LC的同种异体抗原呈递能力存在差异——然而，这些差异不如LC密度差异那么大。患者LC的同种异体抗原呈递能力的降低比例比其外周血单个核细胞的同种异体抗原呈递能力更大。这些结果表明，人类肾移植受者的LC群体明显受到干扰，并且这种干扰在皮肤暴露于阳光的区域最为严重。
