Pandolfi F, Corte G, Quinti I, Fiorilli M, Frieligsdorf A, Bargellesi A, Aiuti F
Clin Exp Immunol. 1983 Mar;51(3):470-4.
Peripheral blood lymphocytes from 17 patients with common variable hypogammaglobulinaemia (CVH) were tested for reactivity with the 5/9 monoclonal antibody which reacts with about 15% of normal T-PBL in which all helper activity is found. In PBL from CVH patients, the proportions of OKT4 and OKT8 positive cells were also determined. Five patients had normal percentages of 5/9 cells and a normal OKT4/OKT8 ratio. Twelve patients had significantly decreased (or absent) 5/9 lymphocytes. Among these, five had decreased 5/9 cells and a normal OKT4/OKT8 ratio and seven had decreased 5/9 cells and an inversion of the OKT4/OKT8 ratio. The deficiency of the helper phenotype T cell subpopulation identified by the 5/9 monoclonal antibody in many patients with CVH may be relevant in the pathogenesis of this disease.
对17例常见变异型低丙种球蛋白血症（CVH）患者的外周血淋巴细胞进行检测，观察其与5/9单克隆抗体的反应性，该抗体可与约15%的正常T-PBL发生反应，而所有辅助活性均存在于这些细胞中。同时，还测定了CVH患者外周血淋巴细胞（PBL）中OKT4和OKT8阳性细胞的比例。5例患者的5/9细胞百分比正常，OKT4/OKT8比值也正常。12例患者的5/9淋巴细胞显著减少（或缺失）。其中，5例患者的5/9细胞减少，但OKT4/OKT8比值正常；7例患者的5/9细胞减少，且OKT4/OKT8比值倒置。许多CVH患者中由5/9单克隆抗体识别的辅助表型T细胞亚群的缺乏可能与该疾病的发病机制有关。
