Giannoulis N, Ogier C, Hast R, Lindblom B, Sjögren A M, Reizenstein P
Am J Hematol. 1984 Feb;16(2):113-21. doi: 10.1002/ajh.2830160203.
Fifty-six patients with acute, non-lymphatic leukemia in the initial phase were studied. The poor prognostic signs were excessive in vitro growth, many HLA-DR-positive cells, or a low ratio of leukemic cell antigenicity to HLA-DR positivity and age. The cells from older patients formed more clusters (P less than 0.05), and they had less capacity to stimulate normal allogeneic lymphocytes (P less than 0.05) than those from younger patients. Cells forming many clusters also were more often (P less than 0.01) HLA-DR-positive than those forming few clusters. It is suggested that the prognosis in old patients with acute leukemia is poor in part because their leukemic cells have characteristics different from those of young patients.
对56例处于初始阶段的急性非淋巴细胞白血病患者进行了研究。预后不良的体征包括体外生长过度、许多HLA - DR阳性细胞，或白血病细胞抗原性与HLA - DR阳性率及年龄的比值较低。老年患者的细胞形成的集落更多（P < 0.05），并且与年轻患者的细胞相比，它们刺激正常异基因淋巴细胞的能力更低（P < 0.05）。形成许多集落的细胞HLA - DR阳性的频率也比形成集落少的细胞更高（P < 0.01）。提示老年急性白血病患者预后不良部分是因为其白血病细胞具有与年轻患者不同的特征。
