Miller K B, Elta G H, Rudders R A, Kaplan M M
Ann Intern Med. 1984 Mar;100(3):385-7. doi: 10.7326/0003-4819-100-3-385.
To ascertain whether abnormalities of circulating T-cell subsets are a cause or effect of primary cirrhosis, we analyzed peripheral blood lymphocytes from 44 patients at various stages of disease. The percentages of total T cells and helper/inducer cells were normal in early disease whereas the percentage of suppressor/inducer cells was increased. The percentage of all T-cell subsets fell steadily as the disease progressed histologically. The percentages in late (cirrhotic) disease were the same as those in patients with other types of cirrhosis. We conclude that most of the previously reported abnormalities of circulating T cells are secondary to the histologic progression of primary biliary cirrhosis.
为了确定循环T细胞亚群异常是原发性胆汁性肝硬化的病因还是结果，我们分析了44例处于疾病不同阶段患者的外周血淋巴细胞。在疾病早期，总T细胞和辅助/诱导细胞的百分比正常，而抑制/诱导细胞的百分比增加。随着疾病组织学进展，所有T细胞亚群的百分比稳步下降。晚期（肝硬化）疾病时的百分比与其他类型肝硬化患者相同。我们得出结论，先前报道的大多数循环T细胞异常是原发性胆汁性肝硬化组织学进展的继发表现。
