Routhier G, Epstein O, Janossy G, Thomas H C, Kung P C, Goldstein G
Lancet. 1980 Dec 6;2(8206):1223-6. doi: 10.1016/s0140-6736(80)92481-2.
There is a significant decrease in the ratio of inducer (helper) to suppressor T lymphocytes in the peripheral blood of patients with primary biliary cirrhosis (PBC). These changes are not seen in other forms of cholestatic liver disease, but are similar to those described in chronic graft-versus-host disease. Cyclosporin A treatment increased the proportion of suppressor A lymphocytes and improved liver function in 6 patients with PBC. This indicates that cyclosporin A is an immunoregulatory drug. Unfortunately nephrotoxicity precluded long-term use.
原发性胆汁性肝硬化（PBC）患者外周血中诱导性（辅助性）T淋巴细胞与抑制性T淋巴细胞的比例显著降低。这些变化在其他形式的胆汁淤积性肝病中未见，但与慢性移植物抗宿主病中描述的变化相似。环孢素A治疗使6例PBC患者的抑制性A淋巴细胞比例增加，并改善了肝功能。这表明环孢素A是一种免疫调节药物。不幸的是，肾毒性使其无法长期使用。
