Thomas H C
Int J Immunopharmacol. 1981;3(3):301-5. doi: 10.1016/0192-0561(81)90023-0.
The proportions of inducer and cytotoxic/suppressor T cells and their concentration in peripheral blood have been determined in patients with acute and chronic type B hepatitis, hepatitis B virus (HBV) carriers with normal hepatic histology, patients with alcohol-induced liver disease (ALD), primary biliary cirrhosis (PBC) and chronic extrahepatic cholestasis. During acute type B hepatitis the inducer/suppressor ratio was decreased due to an increase in suppressor cell concentrations. When this ratio returned to normal the HBs antigen was cleared and HBs antibody was detectable. Similar abnormalities were found in patients with HBs + ve chronic hepatitis. In HBs antigen-positive patients with normal histology, normal T cell subsets were found. In some patients with primary biliary cirrhosis the ratio of inducer to suppressor cells was low due to a reduction in the concentration of inducer cells and in others high due to a reduction in suppressor cells. Administration of cyclosporin A to the latter group produced an increase in the concentration of suppressor cells and there was an improvement in liver biochemistry. In alcohol-induced hepatitis and cirrhosis the ratio of inducer/suppressor cells was normal. Whether these imbalances of the regulatory cells of the immune system in patients with chronic HBV-induced hepatitis and PBC are of primary or secondary importance is uncertain. The relationship of the depressed ratio to persistence of the hepatitis B virus is worthy of further study.
已测定急性和慢性乙型肝炎患者、肝组织学正常的乙肝病毒（HBV）携带者、酒精性肝病（ALD）患者、原发性胆汁性肝硬化（PBC）患者及慢性肝外胆汁淤积患者外周血中诱导性T细胞和细胞毒性/抑制性T细胞的比例及其浓度。在急性乙型肝炎期间，由于抑制性细胞浓度增加，诱导性/抑制性T细胞比例降低。当该比例恢复正常时，HBs抗原被清除且可检测到HBs抗体。在HBs阳性慢性肝炎患者中也发现了类似异常。在肝组织学正常的HBs抗原阳性患者中，T细胞亚群正常。在一些原发性胆汁性肝硬化患者中，诱导性细胞浓度降低导致诱导性细胞与抑制性细胞的比例较低，而在另一些患者中，抑制性细胞减少导致该比例较高。对后一组患者给予环孢素A后，抑制性细胞浓度增加，肝脏生化指标有所改善。在酒精性肝炎和肝硬化患者中，诱导性/抑制性细胞比例正常。慢性HBV诱导的肝炎和PBC患者免疫系统调节细胞的这些失衡是原发性还是继发性尚不确定。该降低的比例与乙肝病毒持续存在的关系值得进一步研究。
