Shinkai T, Tominaga K, Shimabukuro Z, Shimizu E, Eguchi K, Saijo N, Iwashita K, Niitani H
Gan To Kagaku Ryoho. 1984 Jan;11(1):87-96.
Platelet aggregation, plasma beta-thromboglobulin (beta-TG) concentration and coenzyme Q10 content in serum and platelets were measured in 45 patients with unresectable carcinoma of the lung and in 7 patients with metastatic pulmonary tumor before and after receiving chemotherapy. A significant increase in the plasma beta-TG concentration in cancer patients (47.4 +/- 18.7 ng/ml) was observed (p less than 0.001) compared to the controls (30.3 +/- 9.2 ng/ml). Serum coenzyme Q10 content was lower in cancer patients (0.42 +/- 0.19 micrograms/ml) (p less than 0.05) compared to the controls (0.57 +/- 0.24 micrograms/ml). The reason of decrease in serum coenzyme Q10 content in cancer patients was difficult to explain. No significant difference of the coenzyme Q10 content in platelets (1 X 10(8) cells) was observed either cancer patients (12.5 +/- 2.8 ng) or the controls (12.6 +/- 2.1 ng). No significant correlation was noted among platelet aggregation, plasma beta-TG concentration and coenzyme Q10 content in serum and platelets. Administration of either vindesine or KW2083 did not influence the coenzyme Q10 content in platelets. These results suggest that ATP synthetic pathway by oxidative phosphorylation in platelet be maintained in cancer patients, although a significant increase of plasma beta-TG concentration appears to be associated with an acceleration in the metabolic turnover of platelet.
对45例无法切除的肺癌患者和7例转移性肺肿瘤患者在接受化疗前后进行了血小板聚集、血浆β-血小板球蛋白（β-TG）浓度以及血清和血小板中辅酶Q10含量的测定。与对照组（30.3±9.2 ng/ml）相比，癌症患者血浆β-TG浓度显著升高（47.4±18.7 ng/ml）（p<0.001）。与对照组（0.57±0.24μg/ml）相比，癌症患者血清辅酶Q10含量较低（0.42±0.19μg/ml）（p<0.05）。癌症患者血清辅酶Q10含量降低的原因难以解释。癌症患者（12.5±2.8 ng）和对照组（12.6±2.1 ng）血小板（1×10⁸个细胞）中辅酶Q10含量均未观察到显著差异。血小板聚集、血浆β-TG浓度与血清和血小板中辅酶Q10含量之间未发现显著相关性。给予长春地辛或KW2083均不影响血小板中辅酶Q10含量。这些结果表明，尽管血浆β-TG浓度显著升高似乎与血小板代谢周转加速有关，但癌症患者血小板中通过氧化磷酸化的ATP合成途径得以维持。
