Noble C, Norbury K C
J Immunopharmacol. 1983;5(4):341-58. doi: 10.3109/08923978309026453.
Peripheral blood T cells from rats given a single oral dose of dexamethasone (DMS) or cyclophosphamide (CY) exhibited a differential sensitivity to these compounds as measured by lymphoproliferation in the presence of concanavalin A (Con A) or phytohemagglutinin hemagglutinin (PHA). Con A-responsive cells (T Con A) were found to be resistant to the effects of DMS, while the PHA-responsive population (T PHA) showed a dose-dependent suppression at dose levels of 0.35 and 1.00 mg/kg. DMS did not alter serum antibody production against sheep erythrocytes at the dosage level which produced a significant depression of the PHA response. Animals treated with CY showed enhanced Con A-mediated lymphoproliferation at a dose of 15 mg/kg and marked suppression at 45 mg/kg. The PHA-mediated response, however, exhibited only a dose-dependent suppression at both dosage levels. CY had no effect on the antibody response at doses that enhance Con A lymphoproliferation. These results suggest that T helper cells and T suppressor cells are not TpHA cells.
给大鼠单次口服地塞米松（DMS）或环磷酰胺（CY）后，外周血T细胞对这些化合物表现出不同的敏感性，这通过在伴刀豆球蛋白A（Con A）或植物血凝素（PHA）存在下的淋巴细胞增殖来测定。发现对Con A有反应的细胞（T Con A）对地塞米松的作用具有抗性，而对PHA有反应的群体（T PHA）在剂量水平为0.35和1.00 mg/kg时表现出剂量依赖性抑制。在产生PHA反应显著降低的剂量水平下，地塞米松不会改变针对绵羊红细胞的血清抗体产生。用环磷酰胺处理的动物在剂量为15 mg/kg时表现出Con A介导的淋巴细胞增殖增强，在45 mg/kg时表现出明显抑制。然而，PHA介导的反应在两个剂量水平下仅表现出剂量依赖性抑制。在增强Con A淋巴细胞增殖的剂量下，环磷酰胺对抗体反应没有影响。这些结果表明，辅助性T细胞和抑制性T细胞不是T PHA细胞。
