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经皮腔内冠状动脉成形术后急性心肌缺血的外科治疗。主动脉内球囊反搏的作用。

Surgical management of acute myocardial ischemia following percutaneous transluminal coronary angioplasty. Role of the intra-aortic balloon pump.

作者信息

Murphy D A, Craver J M, Jones E L, Curling P E, Guyton R A, King S B, Gruentzig A R, Hatcher C R

出版信息

J Thorac Cardiovasc Surg. 1984 Mar;87(3):332-9.

PMID:6230489
Abstract

Acute myocardial ischemia is a serious complication of percutaneous transluminal coronary angioplasty, often requiring emergency myocardial revascularization. Since our initial report of 17 such patients, we have encountered an additional 32 patients requiring emergency myocardial revascularization since September, 1981. The indication for emergency myocardial revascularization was ischemic chest pain in all 32 patients. Percutaneous transluminal coronary angioplasty resulted in injury to the right coronary artery in 11 patients, the left anterior descending artery in 19 patients, and the left main artery in two patients. The onset of ischemia was immediate in 26 patients but delayed up to 22 hours in six patients. Chest pain was associated with ST-segment elevation in 21 patients, hypotension in 7 patients, and cardiac arrest in 6 patients. Immediate intra-aortic balloon pumping was instituted in the angioplasty suite in 16 patients. The mean time from onset of ischemia to completed revascularization was 156 minutes with a mean of 1.6 grafts performed per patient. Seventeen patients (53%) had enzyme evidence of myocardial infarction postoperatively, with a significantly higher (p less than 0.01) incidence of myocardial infarction in those patients with preoperative ST elevation (76% versus 9%). In the 21 patients with ST-segment elevation, the incidence of Q wave infarction was 20% (3/15) with balloon pumping and 50% (3/6) without balloon pumping. Complications associated with intra-aortic balloon pumping occurred in one patient (6%). There were no hospital or late deaths with follow-up extending 16 months. The spectrum of injury resulting from percutaneous transluminal coronary angioplasty extends from chest pain alone to severe transmural ischemia with hypotension or cardiac arrest. Presentation may be immediate or delayed. Urgent emergency myocardial revascularization remains the accepted therapy for this complication. Immediate preoperative intra-aortic balloon pumping is a useful adjunct to emergency myocardial revascularization in the group of patients with acute ischemia and ST-segment elevation.

摘要

急性心肌缺血是经皮腔内冠状动脉成形术的一种严重并发症,常需进行紧急心肌血运重建。自我们首次报道17例此类患者以来,自1981年9月起我们又遇到另外32例需要紧急心肌血运重建的患者。所有32例患者紧急心肌血运重建的指征均为缺血性胸痛。经皮腔内冠状动脉成形术导致11例患者右冠状动脉损伤,19例患者左前降支损伤,2例患者左主干损伤。26例患者缺血立即发作,但6例患者延迟长达22小时。21例患者胸痛伴有ST段抬高,7例患者伴有低血压,6例患者发生心脏骤停。16例患者在血管成形术操作室立即进行了主动脉内球囊反搏。从缺血发作到完成血运重建的平均时间为156分钟,每位患者平均进行1.6次移植。17例患者(53%)术后有心肌梗死的酶学证据,术前ST段抬高的患者心肌梗死发生率显著更高(p<0.01)(76%对9%)。在21例ST段抬高的患者中,进行球囊反搏的患者Q波梗死发生率为20%(3/15),未进行球囊反搏的患者为50%(3/6)。1例患者(6%)发生了与主动脉内球囊反搏相关的并发症。随访16个月无住院或晚期死亡病例。经皮腔内冠状动脉成形术所致损伤范围从单纯胸痛到伴有低血压或心脏骤停的严重透壁缺血。症状可能立即出现或延迟出现。紧急心肌血运重建仍然是这种并发症公认的治疗方法。对于急性缺血和ST段抬高的患者,术前立即进行主动脉内球囊反搏是紧急心肌血运重建的有用辅助手段。

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