Fehér K G, Koó E, Fehér T
Acta Med Hung. 1983;40(2-3):125-31.
Female patients with "intrinsic" bronchial asthma without corticosteroid therapy for at least 3 months revealed low blood concentration of total protein-unbound + protein-bound) and free (biologically active, protein-unbound) cortisol, dehydroepiandrosterone and dehydroepiandrosterone sulphate, as also a low urinary excretion of dehydroepiandrosterone metabolites. The results suggest that bronchial asthma is associated with hypoadrenia due to an impaired production not only of cortisol, but also of adrenocortical androgens resulting in an insufficient hormone supply of the target organs. These seem noteworthy, since recent observations showed relationships between the immune responsiveness and sex hormones.
在至少3个月未接受皮质类固醇治疗的“特发性”支气管哮喘女性患者中，发现其血液中总蛋白结合（结合蛋白）和游离（生物活性、未结合蛋白）皮质醇、脱氢表雄酮及硫酸脱氢表雄酮的浓度较低，同时尿中脱氢表雄酮代谢产物的排泄量也较低。结果表明，支气管哮喘与肾上腺功能减退有关，这是由于不仅皮质醇的产生受损，而且肾上腺皮质雄激素的产生受损，导致靶器官的激素供应不足。这些结果似乎值得关注，因为最近的观察表明免疫反应性与性激素之间存在关联。
