Gardner R C, Feinerman A E, Kantrowitz P A, Gottblatt S, Loewenstein M S, Zamcheck N
Am J Dig Dis. 1978 Feb;23(2):129-33. doi: 10.1007/BF01073187.
Fifty-seven patients with ulcerative colitis were folloued 1-49 months (mean, 18 months) with serial CEA determinations during periods of remission, mild relapses, and severe relapses. Elevated CEA titers correlated with activity and possibly extent of disease: 12% of patients with proctitis, 47% of patients with left-sided colitis, and 60% of patients with transverse or universal colitis had elevated CEA titers during a flare. Moreover, 24% of patients with mild flares and 86% of patients with severe flares had elevated CEA titers. Ninety-two percent of patients with extensive disease and severe flares had elevated CEA titers. Elevated CEA titers were correlated with histologic findings in three patients. Inflammation of mucosa was demonstrated by colonoscopy and confirmed by biopsy in one patient with persistently elevated CEA titers during clinical remission. In two other patients with active disease whose CEA titers fell prior to colectomy, marked denudation of colonic mucosa was noted. In this study, a transiently elevated CEA titer indicated either clinically active ulcerative colitis or active inflammation of colonic mucosa.
57例溃疡性结肠炎患者接受了1至49个月（平均18个月）的随访，在缓解期、轻度复发期和重度复发期进行了连续癌胚抗原（CEA）测定。CEA滴度升高与疾病活动度及可能的病变范围相关：在病情发作期间，直肠炎患者中有12%、左侧结肠炎患者中有47%、横贯性或全结肠炎患者中有60%的CEA滴度升高。此外，轻度发作的患者中有24%、重度发作的患者中有86%的CEA滴度升高。病变广泛且重度发作的患者中有92%的CEA滴度升高。3例患者的CEA滴度升高与组织学检查结果相关。1例在临床缓解期CEA滴度持续升高的患者，经结肠镜检查证实黏膜有炎症，并经活检确诊。另外2例患有活动性疾病且在结肠切除术前CEA滴度下降的患者，发现结肠黏膜有明显剥脱。在本研究中，CEA滴度短暂升高表明溃疡性结肠炎临床活动或结肠黏膜有活动性炎症。
