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[实验性佐剂性关节炎中的抑制性T细胞与免疫抑制]

[T-suppressors in experimental adjuvant arthritis and immunosuppression].

作者信息

Madzhidov U V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1984 Jan(1):65-8.

PMID:6230839
Abstract

The functional activity of T-suppressors in experimental adjuvant arthritis in CBA and C57BL/6 mice, as well as after the injection of an immunosuppressive agent, has been studied. The successful development of experimental arthritis has been shown to occur simultaneously with essential disturbances (a decrease) in the function of T-suppressors. The injection of batriden, an immunosuppressive agent, into mice at the moment when adjuvant arthritis is induced in the animals leads to an even greater suppression of the function of T-suppressors. The degree to which this function is suppressed in experimental adjuvant arthritis depends on the genotype of mice.

摘要

对CBA和C57BL/6小鼠实验性佐剂性关节炎中T抑制细胞的功能活性,以及注射免疫抑制剂后的功能活性进行了研究。结果表明,实验性关节炎的成功发展与T抑制细胞功能的严重紊乱(降低)同时发生。在给动物诱导佐剂性关节炎时向小鼠注射免疫抑制剂巴替丁,会导致T抑制细胞功能受到更大程度的抑制。在实验性佐剂性关节炎中该功能被抑制的程度取决于小鼠的基因型。

相似文献

1
[T-suppressors in experimental adjuvant arthritis and immunosuppression].[实验性佐剂性关节炎中的抑制性T细胞与免疫抑制]
Zh Mikrobiol Epidemiol Immunobiol. 1984 Jan(1):65-8.
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[Immunosuppression in experimental staphylococcal infection and its effect on antimicrobial resistance].[实验性葡萄球菌感染中的免疫抑制及其对抗菌药物耐药性的影响]
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[Age-related changes in the immune response of mouse (CBA x C57BL)F1 hybrids. II. Effect of hydrocortisone on the specific immunosuppression phenomenon and the role of nonspecific suppressor cells in the antibody formation process in old animals].【小鼠(CBA×C57BL)F1杂种免疫反应的年龄相关变化。II.氢化可的松对特异性免疫抑制现象的影响以及非特异性抑制细胞在老年动物抗体形成过程中的作用】
Ontogenez. 1983 Jan-Feb;14(1):93-6.
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A CD4 cell is capable of transferring suppression of collagen-induced arthritis.CD4细胞能够传递对胶原诱导性关节炎的抑制作用。
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Decreased T-suppressor cell activity in rats with adjuvant arthritis.佐剂性关节炎大鼠中T抑制细胞活性降低。
Ann Rheum Dis. 1983 Dec;42(6):693-8. doi: 10.1136/ard.42.6.693.

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