Madzhidov U V
Zh Mikrobiol Epidemiol Immunobiol. 1984 Jan(1):65-8.
The functional activity of T-suppressors in experimental adjuvant arthritis in CBA and C57BL/6 mice, as well as after the injection of an immunosuppressive agent, has been studied. The successful development of experimental arthritis has been shown to occur simultaneously with essential disturbances (a decrease) in the function of T-suppressors. The injection of batriden, an immunosuppressive agent, into mice at the moment when adjuvant arthritis is induced in the animals leads to an even greater suppression of the function of T-suppressors. The degree to which this function is suppressed in experimental adjuvant arthritis depends on the genotype of mice.
对CBA和C57BL/6小鼠实验性佐剂性关节炎中T抑制细胞的功能活性,以及注射免疫抑制剂后的功能活性进行了研究。结果表明,实验性关节炎的成功发展与T抑制细胞功能的严重紊乱(降低)同时发生。在给动物诱导佐剂性关节炎时向小鼠注射免疫抑制剂巴替丁,会导致T抑制细胞功能受到更大程度的抑制。在实验性佐剂性关节炎中该功能被抑制的程度取决于小鼠的基因型。