Prokopenko L G, Chalyĭ G A
Zh Mikrobiol Epidemiol Immunobiol. 1984 Apr(4):104-8.
The influence of trypsin on the formation of immune response induced by a thymus-dependent antigen at different periods of localized staphylococcal infection has been studied. A single intramuscular injection of bovine trypsin has been found to enhance immune response to sheep red blood cells (SRBC) in healthy mice and, to a still greater degree, in mice with localized staphylococcal infection. the development of localized staphylococcal infection has been shown to have no influence on the manifestation of the immuno-suppressive effect of splenocytes in SRBC-immunized mice or to enhance this effect. The injection of trypsin decreases the immunosuppressive effect of splenocytes in healthy or staphylococcus-infected hyperimmune mice.
研究了在局部葡萄球菌感染的不同时期，胰蛋白酶对胸腺依赖性抗原诱导的免疫反应形成的影响。已发现，单次肌内注射牛胰蛋白酶可增强健康小鼠对绵羊红细胞（SRBC）的免疫反应，在局部葡萄球菌感染的小鼠中增强作用更为明显。已表明，局部葡萄球菌感染的发展对SRBC免疫小鼠脾细胞免疫抑制作用的表现没有影响，或增强这种作用。注射胰蛋白酶可降低健康或葡萄球菌感染的超免疫小鼠脾细胞的免疫抑制作用。
