Anderson A J, Barboriak J J, Rimm A A
Am J Epidemiol. 1978 Jan;107(1):8-14. doi: 10.1093/oxfordjournals.aje.a112511.
An association of coronary artery occlusion, as determined by coronary arteriography with age, prevalence of risk factors and alcohol intake was studied in 1635 male and 371 female heart patients. The degree of coronary artery occlusion was positively related to elevated cholesterol, elevated triglycerides, diabetes, age and history of smoking for both male and female patients. Hypertension was related to the degree of occlusion only for female patients. Male and female patients who had a higher alcohol intake tended to have less extensive occlusion. No positive association was found between obesity and the degree of occlusion. When the patients were divided on the basis of age (less than 50 and greater than or equal to 50 years) the findings did not differ. The lack of finding a relation between obesity and occlusion or between hypertension and occlusion for males differs from the general findings of epidemiologic studies on the relation between these risk factors and coronary heart disease. The authors believe that this discrepancy may either be explained by the way they selected patients (i.e., they selected patients who underwent a diagnostic angiographic examination), or that obesity and hypertension are not directly related to coronary occlusion but influence occlusive disease through some secondary mechanism.
在1635名男性和371名女性心脏病患者中，研究了冠状动脉造影确定的冠状动脉闭塞与年龄、危险因素患病率及酒精摄入量之间的关联。对于男性和女性患者，冠状动脉闭塞程度与胆固醇升高、甘油三酯升高、糖尿病、年龄及吸烟史呈正相关。高血压仅与女性患者的闭塞程度有关。酒精摄入量较高的男性和女性患者往往闭塞程度较轻。未发现肥胖与闭塞程度之间存在正相关。当根据年龄（小于50岁和大于或等于50岁）对患者进行分组时，结果没有差异。男性中未发现肥胖与闭塞之间或高血压与闭塞之间存在关联，这与这些危险因素与冠心病关系的流行病学研究的一般结果不同。作者认为，这种差异可能要么通过他们选择患者的方式来解释（即他们选择接受诊断性血管造影检查的患者），要么肥胖和高血压与冠状动脉闭塞没有直接关系，而是通过一些次要机制影响闭塞性疾病。
