Sorlie P D, Garcia-Palmieri M R, Castillo-Staab M I, Costas R, Oalmann M C, Havlik R
Am J Pathol. 1981 Jun;103(3):345-52.
Among 9824 Puerto Rican men, aged 35-79, participating in a prospective study of cardiovascular risk factors, there were 970 deaths during the period 1965-1977. About 14%, or 139, of these deaths had a protocol autopsy following the procedures of the International Atherosclerosis Project. The percentage of involvement with raised atherosclerotic lesions in the coronary arteries was higher in the urban deceased than in the rural. The coronary heart disease death rate was also found to be higher in urban than in rural men in this population. Serum cholesterol and systolic blood pressure measured from up to 8 years before death were related both to raised lesions in the coronary arteries and in the aorta. Age and previous smoking status were associated with lesions only in the aorta. These results lend support for an etiologic relationship between serum cholesterol and blood pressure and the atherosclerotic process.
在9824名年龄在35至79岁之间、参与心血管危险因素前瞻性研究的波多黎各男性中，1965年至1977年期间有970人死亡。其中约14%，即139例死亡病例按照国际动脉粥样硬化项目的程序进行了尸检。城市死者冠状动脉中动脉粥样硬化病变增加的累及百分比高于农村死者。在该人群中还发现城市男性的冠心病死亡率高于农村男性。死亡前长达8年测量的血清胆固醇和收缩压与冠状动脉和主动脉中病变增加均相关。年龄和既往吸烟状况仅与主动脉中的病变相关。这些结果支持血清胆固醇、血压与动脉粥样硬化过程之间的病因学关系。
