系谱分离分析的效率与稳健性
Efficiency and robustness of pedigree segregation analysis.
作者信息
Go R C, Elston R C, Kaplan E B
出版信息
Am J Hum Genet. 1978 Jan;30(1):28-37.
Abstract
Different pedigree structures and likelihoods are examined to determine their efficiency for parameter estimation under one-locus models. For the cases simulated, family size has little effect; estimates based on unconditional likelihoods are generally more efficient than those based on conditional likelihoods. The proposed method of pedigree analysis under a one-locus model is found to be robust in the analysis of nuclear families: skewness of the data and polygenic inheritance will not lead to the spurious detection of major loci unless they occur simultaneously, and together with a moderate amount of environmental correlation among sibs.
摘要
研究了不同的谱系结构和似然性，以确定它们在单基因座模型下进行参数估计的效率。对于模拟的情况，家庭规模影响较小；基于无条件似然性的估计通常比基于条件似然性的估计更有效。发现在单基因座模型下提出的谱系分析方法在核心家庭分析中具有稳健性：数据的偏态和多基因遗传不会导致主要基因座的虚假检测，除非它们同时出现，并且与同胞之间适度的环境相关性一起出现。
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