尼可地尔可减轻犬冠状动脉闭塞期间的心肌酸中毒。
Nicorandil attenuates myocardial acidosis during coronary occlusion in dogs.
作者信息
Abiko Y, Nishimura T, Sakai K
出版信息
Br J Pharmacol. 1984 Feb;81(2):409-11. doi: 10.1111/j.1476-5381.1984.tb10093.x.
Abstract
In dogs anaesthetized with pentobarbitone, the left anterior descending coronary artery (LAD) was partially occluded. Before and 30 min after partial occlusion, the myocardial pH was 7.52-7.54 and 6.89-6.91, respectively. Nicorandil (50 micrograms kg-1, i.v.) increased the pH that had been reduced by partial occlusion and this effect lasted at least 60 min. Thus nicorandil attenuates ischaemic myocardial acidosis.
摘要
在戊巴比妥麻醉的犬中，左冠状动脉前降支（LAD）被部分阻断。部分阻断前和阻断后30分钟，心肌pH值分别为7.52 - 7.54和6.89 - 6.91。尼可地尔（50微克/千克，静脉注射）使因部分阻断而降低的pH值升高，且该作用至少持续60分钟。因此，尼可地尔可减轻缺血性心肌酸中毒。
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