S-腺苷-L-高半胱氨酸对经对氯苯丙氨酸预处理大鼠睡眠的影响。
Effect of S-adenosyl-L-homocysteine upon sleep in p-chlorophenylalanine pretreated rats.
作者信息
Louis-Coindet J, Sarda N, Pacheco H, Jouvet M
出版信息
Brain Res. 1984 Mar 5;294(2):239-45. doi: 10.1016/0006-8993(84)91035-7.
S-Adenosyl-L-homocysteine (7 mg/kg), administered to PCPA-pretreated rats, was able to restore normal SWS and PS quantities, as well as circadian rhythms. This effect was at its maximum when SAH was injected 48 h after PCPA (400 mg/kg). These results are discussed in terms of post-synaptic synergetic control by SAH of serotonergic and noradrenergic nerve terminals via the periventricular system and caudal medulla in relation to environmental input.
给经对氯苯丙氨酸预处理的大鼠注射S-腺苷-L-高半胱氨酸（7毫克/千克），能够恢复正常的慢波睡眠和快动眼睡眠量以及昼夜节律。当在对氯苯丙氨酸（400毫克/千克）注射后48小时注射S-腺苷-L-高半胱氨酸时，这种效果最为明显。这些结果从S-腺苷-L-高半胱氨酸通过脑室周围系统和延髓尾部对5-羟色胺能和去甲肾上腺素能神经末梢进行突触后协同控制与环境输入的关系方面进行了讨论。
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