[S-腺苷-L-高半胱氨酸：2. 一种抗惊厥药]
[S-adenosyl-L-homocysteine: 2. An anticonvulsant].
作者信息
Fonlupt P, Roche M, Andre A C, Cronenberger L, Pacheco H
出版信息
Can J Physiol Pharmacol. 1980 May;58(5):493-8.
PMID:7417876
Abstract
S-Adenosyl-L-homocysteine (SAH) decreases the epileptiform discharges induced by hippocampic stimulation. SAH reduces the pentetrazol convulsions, does not modify picrotoxine convulsions, and increases strychnine toxicity. These effects are not linked to gamma-aminobutyric acid metabolism perturbation or to the concentration of some amino acids known for their action in synaptic transmission.
摘要
S-腺苷-L-高半胱氨酸（SAH）可减少海马刺激诱导的癫痫样放电。SAH可减轻戊四氮惊厥，不改变印防己毒素惊厥，并增加士的宁毒性。这些作用与γ-氨基丁酸代谢紊乱或某些已知在突触传递中起作用的氨基酸浓度无关。
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