Clarkson A R, Woodroffe A J, Bannister K M, Lomax-Smith J D, Aarons I
Clin Nephrol. 1984 Jan;21(1):7-14.
A review is presented of the current knowledge concerning the syndrome of IgA nephropathy. Primary and secondary forms can now be delineated and this division has improved understanding of immunopathogenetic mechanisms giving rise to glomerular mesangial IgA deposits. Attention is paid to disorders of antigen exclusion at mucosal surfaces, defective reticulo-endothelial sequestration, and altered immunoglobulin A production and regulation. Particular reference is made to these mechanisms with respect to primary IgA nephropathy, Henoch-Schoenlein purpura and mesangial IgA nephritis associated with alcoholic cirrhosis.
本文综述了目前关于IgA肾病综合征的相关知识。现在可以区分原发性和继发性形式，这种划分有助于更好地理解导致肾小球系膜IgA沉积的免疫发病机制。文中关注了黏膜表面抗原排除障碍、网状内皮系统清除功能缺陷以及免疫球蛋白A产生和调节的改变。特别提及了这些机制在原发性IgA肾病、过敏性紫癜和酒精性肝硬化相关的系膜IgA肾炎中的情况。
