Galla J H, Spotswood M F, Harrison L A, Mestecky J
J Clin Immunol. 1985 Sep;5(5):298-306. doi: 10.1007/BF00918248.
To determine the concentrations and molecular forms of urinary IgA in IgA nephropathy and Henoch-Schoenlein purpura, we studied 29 patients with these IgA-associated renal diseases (IgAN). Control groups comprised 10 patients with other diverse renal disease and 11 healthy volunteers. Urinary IgA and IgG concentrations were higher in IgAN than in either control group and correlated positively with the serum creatinine concentration as well as the urinary protein excretion (P less than 0.01). However, IgA/IgG ratios did not differ among the three groups. Polymeric IgA (p-IgA) in the urine predominated only in normals; in IgAN and patients with other renal diseases, monomeric IgA (m-IgA) occurred almost exclusively. Serum IgA concentrations were generally normal in IgAN; four patients had concentrations greater than 500 mg/dl. Although the fraction of p-IgA in serum (median, 18%) was increased above normal (5-10%) in 13 of 16 (81%) subjects, neither the concentration of IgA or IgG nor the amount of p-IgA correlated with the serum creatinine concentration. These data suggest that the molecular form and concentration of urinary IgA are not discriminating for IgAN and are independent of these characteristics of serum IgA.
为了确定IgA肾病和过敏性紫癜中尿IgA的浓度及分子形式，我们研究了29例患有这些IgA相关性肾脏疾病（IgAN）的患者。对照组包括10例患有其他各种肾脏疾病的患者和11名健康志愿者。IgAN患者的尿IgA和IgG浓度高于任何一个对照组，且与血清肌酐浓度以及尿蛋白排泄呈正相关（P<0.01）。然而，三组之间的IgA/IgG比值并无差异。尿中的聚合IgA（p-IgA）仅在正常人中占主导；在IgAN患者和其他肾脏疾病患者中，几乎全部是单体IgA（m-IgA）。IgAN患者的血清IgA浓度一般正常；4例患者的浓度大于500mg/dl。虽然16例（81%）受试者中有13例血清中p-IgA的比例（中位数为18%）高于正常水平（5-10%），但IgA或IgG的浓度以及p-IgA的量均与血清肌酐浓度无关。这些数据表明，尿IgA的分子形式和浓度对IgAN并无鉴别意义，且与血清IgA的这些特征无关。
