Peterson L L
J Am Acad Dermatol. 1984 Feb;10(2 Pt 2):379-84. doi: 10.1016/s0190-9622(84)80011-0.
A 48-year-old white woman who for 3 years had been taking hydralazine, 100 mg three times a day, propranolol, 160 mg twice a day, and chlorothiazide, 500 mg/day, for hypertension suddenly developed rapidly expanding ulcers that looked like pyoderma gangrenosum. Arthralgias, fevers, and occasional shortness of breath were also noted. A pericardial effusion was diagnosed by echocardiography. The antinuclear antibody (ANA) titer on routine mouse liver substrate was initially negative, but the ANA titer was positive (1:1,920) on human epithelioid cell substrate. Antibodies to histones and single-stranded DNA were also elevated. After discontinuing hydralazine, all signs and symptoms cleared over a 4-week period. At the time of discharge the ANA titer had decreased to 1:480.
一名48岁的白人女性，因高血压服用肼屈嗪（每日3次，每次100毫克）、普萘洛尔（每日2次，每次160毫克）和氯噻嗪（每日500毫克）3年，突然出现迅速扩大的溃疡，外观类似坏疽性脓皮病。还注意到关节痛、发热和偶尔的呼吸急促。超声心动图诊断为心包积液。常规小鼠肝脏底物上的抗核抗体（ANA）滴度最初为阴性，但在人上皮样细胞底物上ANA滴度为阳性（1:1920）。组蛋白和单链DNA抗体也升高。停用肼屈嗪后，所有体征和症状在4周内消失。出院时ANA滴度降至1:480。
