Ruiz-Argüelles G J, Katzmann J A, Greipp P R, Marín-López A, González-Llaven J, Cano-Castellanos R
Am J Hematol. 1984 Apr;16(3):267-75. doi: 10.1002/ajh.2830160308.
Lymphocyte subsets were enumerated in a group of 31 patients with aplastic anemia. Abnormal numbers of immunoregulatory T-cells were found in some patients: 26% of them showed a reversed helper/suppressor ratio. Seven of 18 patients showed significantly decreased proliferation in response to PWM; this hyporesponsiveness was present in 75% of patients with a reversed helper/suppressor ratio and in 10% of those with a normal helper/suppressor ratio (R = 0.66, P = 0.008). Eight of 18 patients showed suppressor activity over PWM-induced allogeneic cell proliferation. This suppressive activity did not correlate with T-cell phenotype. Of the patients with a low number of T-cells, 73% had responded to treatment, whereas of those patients with a normal number of T-cells, 26% had responded (P = 0.016). The results are consistent with abnormal immune response in selected patients with aplastic anemia, and suggest a possible influence of T-cells on disease process.
对31例再生障碍性贫血患者的淋巴细胞亚群进行了计数。在一些患者中发现免疫调节性T细胞数量异常：其中26%的患者辅助性T细胞/抑制性T细胞比例倒置。18例患者中有7例对美洲商陆有丝分裂原（PWM）的增殖反应显著降低；这种低反应性在辅助性T细胞/抑制性T细胞比例倒置的患者中占75%，在辅助性T细胞/抑制性T细胞比例正常的患者中占10%（R = 0.66，P = 0.008）。18例患者中有8例对PWM诱导的同种异体细胞增殖具有抑制活性。这种抑制活性与T细胞表型无关。T细胞数量少的患者中，73%对治疗有反应，而T细胞数量正常的患者中，26%对治疗有反应（P = 0.016）。结果表明部分再生障碍性贫血患者存在异常免疫反应，并提示T细胞可能对疾病进程有影响。
