Prottey C, George D, Leech R W, Black J G, Howes D, Vickers C F
Br J Dermatol. 1984 Apr;110(4):475-85. doi: 10.1111/j.1365-2133.1984.tb04663.x.
We have shown that an alcoholic lotion containing ethyl lactate when applied topically to rat skin under occlusion became localized in the follicles and sebaceous glands. When applied to human facial skin the ethyl lactate was hydrolysed to ethanol and lactic acid, and thereby lowered the skin pH. Under such conditions the growth of recoverable skin bacteria, in particular the anaerobe Propionibacterium acnes, was inhibited, and the hydrolysis of sebum to free fatty acids by lipase derived from the bacteria was greatly impaired. These effects of ethyl lactate would account for its observed clinical efficacy in acne vulgaris.
我们已经表明，一种含有乳酸乙酯的酒精洗剂在封闭条件下局部应用于大鼠皮肤时，会定位在毛囊和皮脂腺中。当应用于人类面部皮肤时，乳酸乙酯会水解为乙醇和乳酸，从而降低皮肤pH值。在这种情况下，可恢复的皮肤细菌的生长，特别是厌氧菌痤疮丙酸杆菌的生长受到抑制，并且细菌来源的脂肪酶将皮脂水解为游离脂肪酸的过程也受到极大损害。乳酸乙酯的这些作用可以解释其在寻常痤疮中观察到的临床疗效。
