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抑制N-连接寡糖修剪不会干扰某些整合膜蛋白的表面表达。

Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins.

作者信息

Burke B, Matlin K, Bause E, Legler G, Peyrieras N, Ploegh H

出版信息

EMBO J. 1984 Mar;3(3):551-6. doi: 10.1002/j.1460-2075.1984.tb01845.x.

DOI:10.1002/j.1460-2075.1984.tb01845.x
PMID:6232135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC557385/
Abstract

The effects of 1-deoxynojirimycin (dNM) and 1-deoxymannojirimycin (dMM), inhibitors of oligosaccharide trimming glucosidase I and mannosidase I, respectively, on the biosynthesis of vesicular stomatitis virus G protein, influenza virus hemagglutinin, and human class I histocompatibility antigens were investigated. Although the oligosaccharides of these membrane glycoproteins were greatly altered, neither dNM nor dMM interferred with their surface expression, as determined by a variety of assays, including accessibility to proteases and antibodies; neither did these drugs inhibit production of infectious virus particles.

摘要

分别研究了寡糖修剪葡萄糖苷酶I和甘露糖苷酶I的抑制剂1-脱氧野尻霉素（dNM）和1-脱氧甘露野尻霉素（dMM）对水疱性口炎病毒G蛋白、流感病毒血凝素和人类I类组织相容性抗原生物合成的影响。尽管这些膜糖蛋白的寡糖发生了很大变化，但通过多种测定法（包括蛋白酶和抗体的可及性）确定，dNM和dMM均未干扰它们的表面表达；这些药物也均未抑制感染性病毒颗粒的产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/699c386364ca/emboj00307-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/05535f02656d/emboj00307-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/8015bbc806e8/emboj00307-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/6c3d1d65994e/emboj00307-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/699c386364ca/emboj00307-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/05535f02656d/emboj00307-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/8015bbc806e8/emboj00307-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/6c3d1d65994e/emboj00307-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4add/557385/699c386364ca/emboj00307-0070-a.jpg

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Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions.靶向宿主内质网 α-葡萄糖苷酶的抗病毒治疗：现状与未来方向。
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