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6
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Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins.抑制N-连接寡糖修剪不会干扰某些整合膜蛋白的表面表达。
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9
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10
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本文引用的文献

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Physical and biological properties of influenza virus components obtained after ether treatment.经乙醚处理后获得的流感病毒成分的物理和生物学特性。
J Exp Med. 1960 Nov 1;112(5):765-82. doi: 10.1084/jem.112.5.765.
2
Microsomal glucosidases of rat liver. Partial purification and inhibition by disaccharides.大鼠肝脏微粒体葡萄糖苷酶。部分纯化及二糖对其的抑制作用。
Eur J Biochem. 1980 Dec;113(1):97-103. doi: 10.1111/j.1432-1033.1980.tb06144.x.
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Effect of energy depletion on the glycosylation of a viral glycoprotein.能量耗竭对病毒糖蛋白糖基化的影响。
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4
Carbohydrates of influenza virus. IV. Strain-dependent variations.流感病毒的碳水化合物。IV. 毒株依赖性变异
Virology. 1981 Sep;113(2):584-93. doi: 10.1016/0042-6822(81)90186-0.
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Inhibition of the dolichol pathway of protein glycosylation.抑制蛋白质糖基化的多萜醇途径。
Methods Enzymol. 1982;83:432-43. doi: 10.1016/0076-6879(82)83041-3.
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Synthesis and processing of asparagine-linked oligosaccharides.天冬酰胺连接寡糖的合成与加工
Annu Rev Biochem. 1981;50:555-83. doi: 10.1146/annurev.bi.50.070181.003011.
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Swainsonine: an inhibitor of glycoprotein processing.苦马豆素：一种糖蛋白加工抑制剂。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7393-7. doi: 10.1073/pnas.78.12.7393.
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Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships.糖基转移酶及其在评估寡糖结构和结构-功能关系中的应用。
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9
The lipid pathway of protein glycosylation and its inhibitors: the biological significance of protein-bound carbohydrates.蛋白质糖基化的脂质途径及其抑制剂：蛋白质结合碳水化合物的生物学意义。
Adv Carbohydr Chem Biochem. 1982;40:287-379. doi: 10.1016/s0065-2318(08)60111-0.
10
Fluoroglucose-inhibition of protein glycosylation in vivo. Inhibition of mannose and glucose incorporation into lipid-linked oligosaccharides.体内氟葡萄糖对蛋白质糖基化的抑制作用。对甘露糖和葡萄糖掺入脂质连接寡糖的抑制作用。
Eur J Biochem. 1980 Aug;109(2):331-41. doi: 10.1111/j.1432-1033.1980.tb04799.x.

葡萄糖苷酶抑制剂溴代松柏醇对复合寡糖形成的抑制作用。

Inhibition of formation of complex oligosaccharides by the glucosidase inhibitor bromoconduritol.

作者信息

Datema R, Romero P A, Legler G, Schwarz R T

出版信息

Proc Natl Acad Sci U S A. 1982 Nov;79(22):6787-91. doi: 10.1073/pnas.79.22.6787.

DOI:10.1073/pnas.79.22.6787
PMID:6757922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC347218/
Abstract

The alpha-glucosidase inhibitor bromoconduritol (6-bromo-3,4,5-trihydroxycyclohex-1-ene) inhibits trimming of the innermost glucose residue from the Glc3Man9GlcNAc2 precursor of high-mannose and complex oligosaccharides. This inhibition occurs both in intact cells and with a microsomal enzyme preparation. The formation of lipid-linked oligosaccharides was increased in glucosidase-inhibited cells. Inhibition of transfer of high-mannose oligosaccharides to protein was not observed. In bromoconduritol-treated virus-infected cells, trimming of mannose can occur despite incomplete removal of glucose. The glucosylated high-mannose oligosaccharides GlcMan9GlcNAc, GlcMan8GlcNAc, and GlcMan7GlcNAc were released from viral glycoproteins after digestion with Pronase and endo-beta-N-acetylglucosaminidase H. The formation of complex oligosaccharides was concomitantly inhibited. The release of infectious fowl plague virus particles (an influenza virus) was inhibited from bromoconduritol-treated infected chicken-embryo cells.

摘要

α-葡萄糖苷酶抑制剂溴代康杜立醇（6-溴-3,4,5-三羟基环己-1-烯）可抑制从高甘露糖型和复合寡糖的Glc3Man9GlcNAc2前体中去除最内层葡萄糖残基的修剪过程。这种抑制作用在完整细胞和微粒体酶制剂中均会发生。在葡萄糖苷酶抑制的细胞中，脂质连接寡糖的形成增加。未观察到高甘露糖型寡糖向蛋白质转移的抑制作用。在经溴代康杜立醇处理的病毒感染细胞中，尽管葡萄糖未完全去除，但甘露糖的修剪仍可发生。在用链霉蛋白酶和内切β-N-乙酰葡糖胺酶H消化后，糖基化的高甘露糖型寡糖GlcMan9GlcNAc、GlcMan8GlcNAc和GlcMan7GlcNAc从病毒糖蛋白中释放出来。复合寡糖的形成同时受到抑制。从经溴代康杜立醇处理的感染鸡胚细胞中，传染性禽瘟病毒颗粒（一种流感病毒）的释放受到抑制。