Ritter R C, Balch O K
Am J Physiol. 1978 Jan;234(1):E20-4. doi: 10.1152/ajpendo.1978.234.1.E20.
Adult hamsters did not increase their food intake in response to subcutaneous injection of 2-deoxy-D-glucose (2DG) at doses of 50, 200, 350, 500, 750, 1,000, or 1,500 mg/kg. The failure to feed in response to 2DG was apparent regardless of time of testing and length of test. Hamsters did display marked hyperglycemia after 2DG treatment. Therefore, hamsters do detect and form neural responses to 2DG. In contrast to 2DG, injection of regular insulin, 2, 4, or 8 U/animal, caused hamsters to significantly increase their food intake over a 5-h test period. Furthermore, injection of 4 U of protamine zinc insulin twice daily also caused pronounced increases in food intake and weight gain by hamsters. Because hamsters do not seem to posses a feeding response to 2DG-induced glucoprivation, it seems unlikely that insulin elicits feeding via the glucoprivic control in this species. The results suggest that 1) hamsters lack the glucoprivic control of feeding behavior as exercised by 2DG, 2) 2DG and insulin treatments are not equivalent ingestive challenges, and 3) insulin-induced feeding may result in part from activation of a nonglucoprivic control of food intake.
成年仓鼠皮下注射剂量为50、200、350、500、750、1000或1500mg/kg的2-脱氧-D-葡萄糖（2DG）后，其食物摄入量并未增加。无论测试时间和测试时长如何，仓鼠对2DG均未表现出进食反应。2DG处理后，仓鼠确实出现了明显的高血糖。因此，仓鼠能够检测到2DG并形成神经反应。与2DG不同，注射2、4或8U/只的普通胰岛素会使仓鼠在5小时的测试期内食物摄入量显著增加。此外，每天两次注射4U的精蛋白锌胰岛素也会使仓鼠的食物摄入量和体重显著增加。由于仓鼠似乎对2DG诱导的糖剥夺没有进食反应，胰岛素在该物种中通过糖剥夺控制引发进食的可能性似乎不大。结果表明：1）仓鼠缺乏2DG所行使的对进食行为的糖剥夺控制；2）2DG和胰岛素处理并非等效的摄食刺激；3）胰岛素诱导的进食可能部分源于对食物摄入的非糖剥夺控制的激活。
